These nanoscale carriers represent a highly targeted strategy to cross the Blood-Brain Barrier. By employing surface functionalization, these therapeutic systems are engineered to target endothelial receptors and restore barrier functionality.
Targeting Mechanisms
Transferrin (Tf)-functionalized carriers: These PLGA-based nanoparticles or 2D-HFn (human ferritin-based) structures are conjugated with Transferrin. This allows them to specifically recognize and bind to Transferrin Receptors heavily expressed on brain capillary endothelial cells. This receptor-mediated transcytosis efficiently ferries drugs across the endothelium into the brain parenchyma.
A40-POs: These specialized supramolecular polymersomes are designed to mimic natural ligands that bind to LRP1 (Low-density lipoprotein receptor-related protein 1). By binding to LRP1, A40-POs reset endothelial transport pathways, favoring the natural clearance of toxic amyloid-beta over destructive receptor degradation. This structural restoration actively reverses blood-brain barrier dysfunction.
31 Comments
Big 4 head
Those cricket hooks do some good work
Ayy im early
Eagle claws are goated
I dont even use the sinkers just bibber hook and the worm add the weight to cast
The Certified Runny Poo king is back !
Big ass HEAD..Who doesn't like that
Who else on the porcelain throne watching this
It's hot and I'm lazy this is gona be a quickie is a sentence my wife is sick of hearing 😂
I want to fish with you
Love catching Fat Sallys
I mean 6 inches is goliath. Like you probaby never see that length even.
FO HEADS
Best eating I think
who else watching this while driving
These hooks good for crappie too?
I been catching trout lately but I could go for some forgeads
“It’s hot and I’m lazy, this gon’ be a quickie” I’ve used that one before but in a different context🤣
Back to swimming lol
Danny Gloven 😂😂😂
Absolutely wrong,,no weight
The shoes of deli
Nice
Time to start fishing again.
Listen. That specific dressing…that OG Italian… anything bros. Anything. From deer to dog.
These nanoscale carriers represent a highly targeted strategy to cross the Blood-Brain Barrier. By employing surface functionalization, these therapeutic systems are engineered to target endothelial receptors and restore barrier functionality.
Targeting Mechanisms
Transferrin (Tf)-functionalized carriers: These PLGA-based nanoparticles or 2D-HFn (human ferritin-based) structures are conjugated with Transferrin. This allows them to specifically recognize and bind to Transferrin Receptors heavily expressed on brain capillary endothelial cells. This receptor-mediated transcytosis efficiently ferries drugs across the endothelium into the brain parenchyma.
A40-POs: These specialized supramolecular polymersomes are designed to mimic natural ligands that bind to LRP1 (Low-density lipoprotein receptor-related protein 1). By binding to LRP1, A40-POs reset endothelial transport pathways, favoring the natural clearance of toxic amyloid-beta over destructive receptor degradation. This structural restoration actively reverses blood-brain barrier dysfunction.
I do the same but rig mine drop shot style
This is the best education I’ve had on fishing. Thanks 🙏
Respect Big Bro
How do you know what set-up to use and where?
That looks really good my friend
Love the vids, Wade! Keep killing them Fo' Heads!